The draw has been kind for the Gunners as they will be at home to Championship side Bristol City.
Arsenal youngster Maddie Earl is currently on loan at Bristol trying to gain first team football experience.
There are two all-WSL ties: West Ham v Liverpool and Everton v Tottenham. Charlton at Chelsea and Ipswich or Bournemouth at Man City will hope for a giant-killing upset.
The full draw
1 London Bees v Rugby Borough
2 Leicester City v Stoke City
3 West Ham United v Liverpool
4 Arsenal v Bristol City
5 Chelsea v Charlton Athletic
6 Exeter City v Sunderland
7 Cheltenham Town v Wolverhampton Wanderers
8 Brighton & Hove Albion v Durham
9 Newcastle United v Nottingham Forest or Burnley
10 Kidderminster Harriers or Blackburn Rovers v Portsmouth
11 Manchester City v Ipswich Town or AFC Bournemouth
12 Aston Villa v Oxford United or Bristol Rovers
13 Everton v Tottenham Hotspur
14 Manchester United v West Bromwich Albion
15 Crystal Palace v Sheffield United
16 Fulham v London City Lionesses
Games will be played on the week-end 11-12 January 25, a week before the League restarts.