Francis Coquelin may miss out on the game against Arsenal tonight after he had to withdraw from training on Wednesday.

The former Arsenal midfielder missed out on the first leg due to suspension and has now picked up an ankle/calf problem.

Coquelin ruptured his Achilles requiring surgery and there is concern due to the fact that the pain he felt during training was in the same spot.

Speaking before the game, Coquelin mentioned how special this game was to him. He was asked if it was an extra motivation to play against Arsenal for the first time. “Of course,” he replied. “[I’m] very motivated, more now because I did not play in the first leg but I have the opportunity to pass this round, it would be a very special feeling to spend and make history with this club.”

There has been no confirmation if he will miss the game but Superdeporte claims it should not be a problem if he does given that Valencia already changed their system to accommodate his absence in the first leg.

Arsenal sold the 27-year-old for £12.6m last January. This season he has 39 appearances in all competitions.