Arsenal face Manchester United in their last ‘big six’ clash of the Premier League campaign on Sunday, with a place in the top four up for grabs.

After Arsenal suffered a disappointing 10-man defeat to Rennes on Thursday, they need to pick themselves up for the biggest remaining game of their league season. Manchester United sit just one point ahead of the Gunners in fourth, but Chelsea could overtake both if they win their game in hand.

As a result, a win may be necessary to really push for that final Champions League spot. It won’t be easy though, with United on a fantastic run of away wins including one at the Emirates in the FA Cup.

At least one of the goalscorers from that day will miss out, with Alexis Sanchez injured. Jesse Lingard could also miss out, though he is back in training, as is Anthony Martial. As for Arsenal, let’s have a look at our predicted lineup for the clash.

1Goalkeeper and Defence

LONDON, ENGLAND - FEBRUARY 27: Bernd Leno of Arsenal celebrates his sides fourth goal during the Premier League match between Arsenal FC and AFC Bournemouth at Emirates Stadium on February 27, 2019 in London, United Kingdom. (Photo by Catherine Ivill/Getty Images)
LONDON, ENGLAND – FEBRUARY 27: Bernd Leno of Arsenal celebrates his sides fourth goal during the Premier League match between Arsenal FC and AFC Bournemouth at Emirates Stadium on February 27, 2019, in London, United Kingdom. (Photo by Catherine Ivill/Getty Images)

After missing out in midweek, Bernd Leno should be back in goal. The German goalkeeper made a couple of fantastic saves against Tottenham Hotspur last week, so the fans will be hoping he can repeat the trick against Manchester United.

Sokratis’ red card on Thursday will likely force Emery into a couple of decisions. The Greek international may as well start this one, as there’s no point resting him for Thursday anymore. Then one of Laurent Koscielny and Shkodran Mustafi will probably drop to the bench to keep them fit for the second leg.

That will most likely be Mustafi, with his place on the right being taken by Stephan Lichtsteiner. This entire plan revolves around the Swiss international being fit though, as he’s now missed out on a couple of matchday squads for unexplained reasons. If he’s out, Arsenal may well go with a back three and Ainsley Maitland-Niles on the right.

On the left, Sead Kolasinac should start. Nacho Monreal made a couple of mistakes in midweek, and the Bosnian played well last time he faced United.

Click ‘Next’ for Midfield, Forwards and the full Predicted Starting XI

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Arsenal vs Manchester United Betting Tips

Alexandre Lacazette has five goals in his last seven league games, and he was unlucky not to be awarded one against Manchester United earlier this season. Bet on Lacazette to score anytime with BetUK at 5/4.

Both teams have scored in each of the last four meetings between the two sides. Bet on BTTS with BetUK at 5/9.

Manchester United haven’t kept a clean sheet against Arsenal since 2014. Bet on the Gunners to score over 0.5 goals with BetUK at 1/5.

Prediction: Arsenal 2-1 Manchester United (27/4 with BetUK).