With Chelsea only managing to secure one win so far this season, the pressure is on the Blues to get a result at Stamford Bridge.
A loss midweek for Arsenal in the Champions League means the Gunners will be looking to bounce back after the disappointing result, while a 4-0 win for the Blues will mean their confidence will, in theory, be sky-high going into the London derby.
Arsenal are without Danny Welbeck, Jack Wilshere and Tomas Rosicky, while Chelsea are missing their number one goalkeeper, Thibaut Courtois and forward, Willian.
Here are the official teams:
Chelsea: Begovic; Ivanovic (c), Zouma, Cahill, Azpilicueta; Matic, Fabregas; Pedro, Oscar, Hazard; Diego Costa.
Subs: Blackman, Terry, Mikel, Ramires, Loftus-Cheek, Falcao and Remy.
Arsenal: Cech; Bellerin, Gabriel, Koscielny, Monreal; Coquelin, Cazorla, Ramsey, Ozil, Alexis, Walcott.
Subs: Ospina, Debuchy, Gibbs, Arteta, Oxlade-Chamberlain, Giroud.
VIDEO: The @Arsenal team arrive at Stamford Bridge ahead of #CFCvAFC pic.twitter.com/uS7H8jT6pL
— Arsenal FC (@Arsenal) September 19, 2015