Arsenal could be without Laurent Koscielny, Sead Kolasinac and Mesut Ozil for their Premier League meeting with defending champions Chelsea on Wednesday evening.

The injury concerns are beginning to mount as Arsenal lost three more players over the weekend. Mesut Ozil was ruled out of the 1-1 draw with West Brom due to a knee injury.

The German is now is a doubt for the visit of Chelsea on Wednesday night, though there is hope that he’ll recover in time. Arsenal lost two defenders during the game itself.

Sead Kolasinac hobbled off with what looked like a knee injury in the second half, and had to be replaced by Ainsley Maitland-Niles.

LONDON, ENGLAND – OCTOBER 28: Sead Kolasinac of Arsenal celebrates scoring his sides first goal during the Premier League match between Arsenal and Swansea City at Emirates Stadium on October 28, 2017 in London, England. (Photo by Dan Mullan/Getty Images)

The Bosnian had only returned to the side in the last few days, but picked up the knock in a challenge with West Brom midfielder Gareth Barry.

Laurent Koscielny also pulled up during the second half, with what seemed to be a flare up of his chronic achilles problem. The Frenchman has played several games in a short space of time.

It means Arsenal could be without six first-team players for Wednesday. Aaron Ramsey is yet to return from a hamstring injury he picked up in the 1-1 draw with Southampton.

Nacho Monreal is still a few days off returning, while Olivier Giroud won’t recover from his hamstring problem until mid-January.