Arsenal enter their first Capital One Cup match after a disappointing 2-0 loss to Chelsea in the Premier League.
Spurs, however, go in off the back of a 1-0 win against Crystal Palace.
Gabriel had his red card and three match ban, which he picked up at Stamford Bridge, rescinded but Santi Cazorla (red card) and Francis Coquelin (knee injury) are both set to miss out.
Here are how the teams line up.
Spurs: Vorm, Trippier, Fazio, Wimmer, Rose; Carroll, Dier; Chadli, Eriksen, Townsend; Kane.
Subs: Lloris, Walker, Vertonghen, Winks, Alli, Clinton, Son.
Arsenal: Ospina, Debuchy, Mertesacker, Chambers, Gibbs, Arteta, Flamini, Ox, Ramsey, Campbell, Giroud.
Subs: Macey, Bellerin, Monreal, Ozil, Iwobi, Alexis, Walcott.
.@mertesacker returns to partner @CalumChambers95 in defence. We are an hour away from kick-off at White Hart Lane! pic.twitter.com/CnpZMx2DND
— Arsenal FC (@Arsenal) September 23, 2015